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Key Publications

  1. Verkerke A.R.P, Wang D., Yoshida N., Taxin Z.H., Shi X., Zheng S., Li Y., Auger C., Oikawa S., Yook J.S., Granath-Panelo M., He W., Zhang G.F., Matsushita M., Saito M., Gerszten R.E., Mills E.L., Banks A.S., Ishihama Y., White P.J., McGarrah R.W., Yoneshiro T., Kajimura S. BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis. Cell. 2024 May 9;187(10):2359-2374.e18. PMID: 38653240.
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  2. Yook J.S., Taxin Z.H., Yuan B., Oikawa S., Auger C., Mutlu B., Puigserver P., Hui S., & Kajimura S. The SLC25A47 locus controls gluconeogenesis and energy expenditure. PNAS 2023 Feb 28;120(9):e2216810120. PMID: 36812201.
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  3. Wang Q., Li H., Tajima K., Verkerke A.R.P., Taxin Z.H., Hou Z., Cole J.B., Li F., Wong J., Abe I., Pradhan R.N., Yamamuro T., Yoneshiro T., Hirschhorn J.N., & Kajimura S. (2022) Post-translational control of beige fat biogenesis via PRDM16 stabilization. Nature Sep;609(7925):151-158. PMC9433319
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  4. Abe I., Oguri Y., Verkerke A.R.P., Monteiro L.B., Knuth C.M., Auger C., Qiu Y., Westcott G.P., Cinti S., Shinoda K., Jeschke M.G., & Kajimura S. (2022) Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation. Developmental Cell 57(23):2623-2637. PMC9875052
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  5. Oguri Y., Shinoda K., Kim H., Alba D., Bolus W.R., Brown Z., Pradhan R.N., Tajima K., Yoneshiro T., Ikeda K., Chen C., Cheang R.T., Tsujino K.R., Greiner V.J., McManus M.T., Koliwad S., Spiegelman B.M., and Kajimura S. CD81 controls beige progenitor cell growth and energy balance through Integrin-FAK signaling. Cell 2020; Jun 26: S0092-8674(20)30753-4. PMID: 32615086. PMC7415677.
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  6. Yoneshiro, T., Wang, Q., Tajima, K., Matsushita, M., Maki, H., Igarashi, K., Dai, Z., White, P. J., McGarrah, R. W., Ilkayeva, O., Deleye, Y., Oguri, Y., Kuroda, M., Ikeda, K., Li, H., Ueno, A., Ohishi, M., Ishikawa, T., Kim, K., Chen, Y., Sponton, C. H., Pradhan, R. N., Majd, H., Greiner, V. J., Yoneshiro, M., Brown, Z., Chondronikola, M., Takahashi, H., Goto, T., Kawada, T., Sidossis, L., Szoka, F. C., McManus, M. T., Saito, M., Soga, T., & Kajimura S. (2019) BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature (Article) 572(7771):614-619. PMC6715529 [Research highlight in NEJM 2019, Nature Metabolism 2019, Nature Reviews Endocrinology 2019, TIME etc.]
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  7. Chen Y., Ikeda K., Yoneshiro T., Scaramozza, A., Tajima, K., Wang, Q., Kim K., Shinoda K., Henrique- Sponton C., Brown Z., Brack A., & Kajimura S. (2019) Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature (Article) 565(7738):180-185. PMC6328316 [Research highlight in Nature 2019, Nature Reviews Endocrinology 2019, Faculty1000]
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  8. Tajima K., Ikeda K., Chang H.Y., Chang C.H., Yoneshiro T., Oguri Y., Jun H., Wu J., Ishihama Y., & Kajimura S. (2019). Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nature Metabolism 1, 886-898.
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  9. Tajima K., Ikeda K., Tanabe Y., Thomson E.A., Yoneshiro T., Oguri Y., Ferro M., Poon A.S.Y., and Kajimura S. Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. Nature Communications 2020 11(1):1730. PMID: 32265443. PMC7138828.
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  10. Hasegawa Y., Ikeda K., Chen Y., Alba D., Stifler D., Shinoda K., Hosono T., Maretich P., Yang Y., Ishigaki Y., Chi J., Cohen P., Koliwad S., & Kajimura S. (2018) Repression of adipose tissue fibrosis through a PRDM16-GTF2IRD1 complex improves systemic glucose homeostasis. Cell Metabolism 27(1), 180-194. PMC5727902 [Selected in Faculty1000]
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  11. Ikeda K., Kang Q., Yoneshiro T., Camporez J.P., Maki H., Homma M., Shinoda K., Lu X., Maretich P., Ajuwon K.M., Soga T., & Kajimura S. (2017). UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nature Medicine (12):1454-1465PMC5727902 [Research highlight in Nature Medicine 2017; Nature Reviews Endocrinology 2017; Cell Metabolism; 2017, Science Signaling 2017, TIME, Faculty1000]
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  12. Altshuler-Keylin S., Shinoda K., Hong H., Hasegawa Y., Ikeda K., Yang Y., Perera R.M., Debnath J., & Kajimura S. (2016) Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance. Cell Metabolism 24(3):402-19. PMC5023491 [Research highlight in Cell Metabolism 2016; Nature Reviews Endocrinology 2016]
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  13. Shinoda K., Ohyama K., Hasegawa Y., Chang H-Y., Ogura M., Sato A., Hong H., Hosono T., Sharp L.Z., Scheel D.W., Graham M., Ishihama Y., & Kajimura S. (2015) Phosphoproteomics Identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure.  Cell Metabolism 22(6):997-1008. [Research highlight in Cell Metabolism 2015]
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  14. Shinoda K., Luijten I.H.N., Hasegawa Y., Hong H., Sonne S.B., Xue R., Chondronikola M., Kim M., Cypess A.M., Tseng Y., Nedergaard J., Sidossis L.S., & Kajimura S. (2015). Genetic and functional characterization of clonally-derived adult human brown adipocytes. Nature Medicine 21(4):389-94. PMC4427356 [Research highlight in Nature Medicine 2015]
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  15. Ohno H., Shinoda K., Ohyama K., Sharp L.Z., & Kajimura S.  (2013) EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 504(7478):163-67. PMC3855638 [Research highlight in Cell Metabolism 2014, Selected in Faculty1000, NIH director’s blog]
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  16. Ohno H., Shinoda K., Spiegelman B.M. & Kajimura S.  (2012) PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metabolism 15(3), 395-404.PMC3410936    
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