Kurosu, Hiroshi, Masaya Yamamoto, Jeremy Clark, Johanne Pastor, Animesh Nandi, Prem Gurnani, Owen McGuinness, et al. 2005. “Suppression of Aging in Mice by the Hormone Klotho”. Science 309 (5742): 1829-33.
Abstract
A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.
Last updated on 03/08/2023