Brown Fat and Cardiovascular Health
A Leducq Foundation Funded Network examining brown fat and cardiovascular health through genetic determinants and molecular mechanisms.
Our Team
Team
The goal of our highly interdisciplinary proposal is to elucidate genetic determinants of human brown fat function and the molecular mechanisms underlying its metabolic and cardiovascular benefits. During our first year of funding, our collaborative team has already made significant progress towards these goals.
European Coordinator
Sadaf Farooqi, University of Cambridge (UK)
North American Coordinator
Robert Gerszten, Beth Israel deaconess Medical Center (USA)
Members
- Paul Cohen, Rockefeller University (USA)
- Mariona Graupera, Josep Carreras Leukemia Research Institute (Spain)
- Yuval Itan, Icahn School of Medicine at Mount Sinai (USA)
- Tayfun Ozcelik, Bilkent University (Turkey)
- Rhian Touyz, Research Institute of the McGill University Health Centre (Canada)
- Thomas Wang, UT Southwestern Medical Center (USA)
Member Labs
Research Areas
The goal of our highly interdisciplinary work is to determine the basis for the metabolic and cardiovascular benefits of brown fat. We will achieve this goal through three aims: investigating genetic regulation of brown fat function, studying the cardiovascular and metabolic benefits conferred by brown fat, and identifying effectors and circulating biomarkers of brown fat function. This research has the potential to identify entirely new therapeutic targets to disrupt the connection between obesity and associated cardiovascular and metabolic diseases.
Genetic Regulation
Investigating the genetic regulation of brown fat function
Cardiometabolic Mechanisms
Studying the cardiovascular and metabolic benefits conferred by brown fat
Effectors and Biomarkers
Identifying effectors and circulating biomarkers of brown fat function